1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
ASP3026
CAS: 1097917-15-1
Molecular Formula: C29H40N8O3S
1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- - Names and Identifiers
1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- - Physico-chemical Properties
| Molecular Formula | C29H40N8O3S |
| Molar Mass | 580.74 |
| Density | 1.276 |
| Boling Point | 794.3±70.0 °C(Predicted) |
| pKa | 8.14±0.42(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | ASP3026 showed more selective inhibition of ALK activity in tyrosine kinase than pf02341066. ASP3026 inhibits the growth of the Endogenously expressed NCI-H2228 mutant 3 in the human non-small cell lung cancer tumor cell line EML4-ALK with an IC 50 of 64.8 nM. ASP3026 showed stronger selective inhibition of ALK activity in tyrosine kinase than pf02341066. ASP3026 inhibits the growth of the Endogenously expressed NCI-H2228 mutant 3 in the human non-small cell lung cancer tumor cell line EML4-ALK with an IC 50 of 64.8 nM. |
| In vivo study | Given to subcutaneous NCI-H2228 tumor xenograft mice for oral administration of ASP3026 twice daily for 14 days, induced a dose-dependent antitumor effect, with onset of action at 1 mg/kg, 30 and 100 mg/kg have a strong inhibitory effect. administration of ASP3026 orally twice daily for 14 days to subcutaneous NCI-H2228 tumor xenograft mice induced a dose-dependent antitumor effect, with onset of action at 1 mg/kg, 30 and 100 mg/kg have a strong inhibitory effect. |
1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.722 ml | 8.61 ml | 17.219 ml |
| 5 mM | 0.344 ml | 1.722 ml | 3.444 ml |
| 10 mM | 0.172 ml | 0.861 ml | 1.722 ml |
| 5 mM | 0.034 ml | 0.172 ml | 0.344 ml |
Last Update：2024-01-02 23:10:35
![1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-](http://res.chembk.com/assets/images/structure/300843.gif)
Supplier List
Spot supply
Product Name: ASP3026 Visit Supplier Webpage Request for quotationCAS: 1097917-15-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: ASP3026 Visit Supplier Webpage Request for quotationCAS: 1097917-15-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History